The journal Chemical Reviews has published an article co-authored by researchers from the Faculty of Biochemistry, Biophysics and Biotechnology – Dr hab. Marcin Sarewicz, Dr Sebastian Pintscher, Dr Rafał Pietras, Dr Arkadiusz Borek, Dr Łukasz Bujnowicz and Prof. Artur Osyczka.
The paper, comprising 89 pages and 763 citations, contains hitherto acquired information on molecular mechanisms of mitochondrial and bacterial bc1 cytochrome and photosynthetic b6f cytochrome complexes.
Researchers have put particular emphasis on the latest developments related to ‘the mechanisms of energy-conserving bifurcation of electron pathway and energy-wasting superoxide generation at the quinol oxidation site, the mechanism by which semiquinone is stabilized at the quinone reduction site, interactions with substrates and specific inhibitors, intermonomer electron transfer and the role of a dimeric complex, and higher levels of organization and regulation that involve Cytsbc1/b6f’.
The article, entitled Catalytic Reactions and Energy Conservation in the Cytochrome bc1 and b6f Complexes of Energy-Transducing Membranes, can be found here: pubs.acs.org/doi/10.1021/acs.chemrev.0c00712.