The latest issue of Nature Communications features a paper co-authored by Dr Agata Szade from the JU Faculty of Biochemistry, Biophysics and Biotechnology Department of Medical Biotechnology. The paper presents a molecular map of blood vessels in lymph nodes and defines the subpopulations of endothelium cells that participate in leukocyte recruitment.
The progress of an inflammatory state is regulated by specialised endothelial cells that control the flow of leukocytes from blood to lymphoid tissue. The physiological interaction between leukocytes and endothelial cells have been studied for years and are relatively well documented. However, the diversity of blood vascular endothelial cells (BEC) and their source during angiogenesis have not yet been adequately researched.
Through RNA sequencing on the level of a single cell, the authors have defined and characterised several subpopulations of BEC cells. Understanding the mechanisms regulating angiogenesis in lymphoid tissues may lead to the development of new strategies of precise control of an inflammatory state.
The paper A molecular map of murine lymph node blood vascular endothelium at single cell resolution was written during Dr Agata Szade’s internship at Prof. Eugene Butcher’s laboratory at Stanford University.